GOPC Antibody [F21D16]

Catalog No.: F1335

    Home Primary Antibodies GOPC Antibody [F21D16]

    For research use only.

    Application: Reactivity:

    Usage Information

    Dilution
    1:1000
    Application
    WB
    Reactivity
    Human
    Source
    Rabbit Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years
    Predicted MW
    59 kDa

    Datasheet & SDS

    Biological Description

    Specificity
    GOPC Antibody [F21D16] detects endogenous levels of total GOPC protein.
    Clone
    F21D16
    Synonym(s)
    Golgi-associated PDZ and coiled-coil motif-containing protein; CFTR-associated ligand; Fused in glioblastoma; PDZ protein interacting specifically with TC10; PIST; GOPC; CAL; FIG
    Background
    GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein), also known as FIG or PIST, is a pivotal scaffolding protein localized primarily to the trans-Golgi network, characterized by two N-terminal coiled-coil domains and a C-terminal PDZ domain. Its main functional role centers on mediating vesicular trafficking and regulating the sorting and surface expression of various membrane proteins, including ion channels, receptors, and adhesion molecules. GOPC interacts with golgin-160 and the Q-SNARE protein syntaxin 6 through its coiled-coil domains, facilitating cargo transport in secretory and endocytic pathways. The PDZ domain specifically binds to the C-termini of target proteins such as Frizzled receptors, neuroligins, and CFTR, thus influencing processes like cell signaling, tight junction integrity, and receptor recycling. GOPC is essential in maintaining epithelial cell polarity, regulating tight junctions, and modulating cellular homeostasis. Moreover, GOPC gains pathological significance in glioblastoma, where fusion with ROS tyrosine kinase leads to constitutive kinase activity driving oncogenesis.
    References
    • https://pubmed.ncbi.nlm.nih.gov/25616555/
    • https://pubmed.ncbi.nlm.nih.gov/16882988/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
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