CXCR4 Antibody [G11H20]

Catalog No.: F2178

    Home Primary Antibodies CXCR4 Antibody [G11H20]

    For research use only.

    Application: Reactivity:

    Usage Information

    Dilution
    1:100
    1:500
    1:550
    1:1900
    Application
    WB, IHC, IF, FCM
    Reactivity
    Mouse, Rat, Human
    Source
    Rabbit Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years
    Predicted MW Observed MW
    39 kDa 43 kDa, 42 kDa,47 kDa, 41 kDa
    *Why do the predicted and actual molecular weights differ?
    The following reasons may explain differences between the predicted and actual protein molecular weight.

    Datasheet & SDS

    Biological Description

    Specificity
    CXCR4 Antibody [G11H20] detects endogenous levels of total CXCR4 protein.
    Clone
    G11H20
    Synonym(s)
    CD184; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; LESTR; LAP-3; SDF-1 receptor; CXCR4
    Background
    CXCR4, or C-X-C chemokine receptor type 4, is a G protein-coupled receptor (GPCR) classified within the chemokine receptor family. It is broadly expressed in tissues including immune cells (T and B lymphocytes), the bone marrow, brain, and heart, where it mediates responses essential for cell migration and proliferation by binding to its specific ligand CXCL12 (stromal cell-derived factor 1). CXCR4 consists of seven transmembrane alpha-helices characteristic of GPCRs, with extracellular loops and an N-terminal domain crucial for high-affinity ligand binding. Conserved disulfide bonds stabilize these extracellular components to shape the chemokine binding pocket, which operates according to a "two-site" model involving the chemokine core domain and its N-terminal signaling trigger. CXCR4 regulates hematopoiesis, immune cell trafficking, angiogenesis, and tissue regeneration through activating signaling pathways, including PI3K/AKT and MAPK. It also guides progenitor cell homing to the bone marrow and coordinates immune surveillance. CXCR4 is implicated in cancer metastasis via tumor cell migration and invasion, and serves as a critical HIV co-receptor facilitating viral entry into CD4+ T cells.
    References
    • https://pubmed.ncbi.nlm.nih.gov/32983169/
    • https://pubmed.ncbi.nlm.nih.gov/20929726/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
    If you have any other enquiries, please leave a message.

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