CAS No. 2734853-80-4
Batch:
Purity:98.49
Chemical Structure
Check the
ZYS-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4S,5S)-2-(6-amino-2-fluoropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol | |
|---|---|---|
| CAS Number | 2734853-80-4 | |
| Molecular Formula |
C10H11ClFN5O3 |
|
| Molecular Weight (MW) | 303.68 | |
| InChIKey | HSCKXTNMVCTWGY-UUOKFMHZSA-N |
Fludarabine-Cl (ZYS-1) is a small-molecule inhibitor targeting adenosine deaminase acting on RNA 1 (ADAR1). By inhibiting ADAR1-mediated RNA editing, ZYS-1 suppresses prostate cancer cell proliferation, invasion, and metastatic potential. Furthermore, pharmacological inhibition of ADAR1 activates innate immune signaling pathways, thereby potentiating antitumor immune responses and enhancing the therapeutic efficacy of immune checkpoint blockade immunotherapy in cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(200.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.