CAS No. 1640282-42-3
Batch:
Purity:95.72
Chemical Structure
Check the
Zunsemetinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methyl-4-pyridinyl]-6-methylpyridin-2-one | |
|---|---|---|
| CAS Number | 1640282-42-3 | |
| Molecular Formula |
C25H22ClF2N5O3 |
|
| Molecular Weight (MW) | 513.92 | |
| InChIKey | FQPQMJULRZINPV-UHFFFAOYSA-N |
Zunsemetinib (ATI-450, CDD-450) is a selective inhibitor of the p38α mitogen-activated protein kinase-activated protein kinase 2 (p38α–MK2) signaling axis. It selectively blocks p38α-mediated activation of the downstream proinflammatory kinase MK2 while sparing other p38α substrates like ATF2. This targeted inhibition accelerates the mRNA decay of key pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, suppressing inflammasome priming signals and reducing inflammatory responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.