CAS No. 3084542-49-1
Batch:
Purity: 98.35
Chemical Structure
Check the
ZSA-51
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 3-(6,7-dimethoxy-1,3-dioxo-[1]benzothiolo[2,3-c]pyrrol-2-yl)propanoate | |
|---|---|---|
| CAS Number | 3084542-49-1 | |
| Molecular Formula |
C16H15NO6S |
|
| Molecular Weight (MW) | 349.36 | |
| InChIKey | RTHGCGQMIJRVFB-UHFFFAOYSA-N |
ZSA-51 is a potent oral agonist of stimulator of interferon genes (STING). Activation of STING stimulates the downstream TBK1/IRF3 signaling pathway, triggering the production of type I interferons and proinflammatory cytokines. This cascade remodels the tumor immune microenvironment, promoting immune cell infiltration and driving potent antitumor immune responses in colon and pancreatic cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
9 mg/mL
(25.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.