CAS No. 2648641-36-3
Batch:
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Chemical Structure
Check the
Zotizalkib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentazapentacyclo[19.3.1.04,24.010,15.017,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one | |
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| CAS Number | 2648641-36-3 | |
| Molecular Formula |
C21H20F3N5O3 |
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| Molecular Weight (MW) | 447.41 | |
| InChIKey | ILAMRXVQSGVCJX-AWEZNQCLSA-N |
Zotizalkib (TPX-0131) is a compact, CNS-penetrant macrocyclic inhibitor of wild-type ALK (IC50 = and ALK-resistant mutations. By targeting ALK kinase activity, it inhibits downstream oncogenic signaling pathways, suppressing cellular proliferation and inducing apoptosis in ALK-driven non-small cell lung cancer models. These effects demonstrate potent antitumor efficacy across various mutant ALK-expressing phenotypes. [1]
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.