CAS No. 1620458-09-4

Batch: Purity:99.89
Check CoA
Zoliflodacin(ETX0914; AZD0914) Chemical Structure
Chemical Structure
Check the Zoliflodacin(ETX0914; AZD0914) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione
CAS Number 1620458-09-4
Molecular Formula

C22H22FN5O7
Molecular Weight (MW) 487.44
SMILES CC1CN2C(C(O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6C(COC6=O)C)C(=O)NC(=O)NC3=O
InChIKey ZSWMIFNWDQEXDT-ZESJGQACSA-N

Biological Activity

Zoliflodacin (ETX0914, AZD0914) is a first-in-class oral spiropyrimidinetrione antibiotic that targets bacterial type II topoisomerases, specifically DNA gyrase B (GyrB) and topoisomerase IV. By stabilizing DNA cleavage complexes and blocking bacterial DNA replication, it disrupts essential bacterial cell division pathways. This unique mechanism of action confers potent antibacterial activity against multidrug-resistant pathogens, particularly Neisseria gonorrhoeae. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 97 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Alm RA, et al. Antimicrob Agents Chemother. 2015;59(3):1478-86.

Jump to

Note: Technical data last updated: Sep 1, 2026.