CAS No. 1021868-92-7
Batch:
Purity:99.92
Chemical Structure
Check the
ZM 39923 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;hydrochloride | |
|---|---|---|
| CAS Number | 1021868-92-7 | |
| Molecular Formula |
C23H25NO.HCl |
|
| Molecular Weight (MW) | 367.91 | |
| SMILES | CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC3=CC=CC=C3.Cl | |
| InChIKey | NJTUORMLOPXPBY-UHFFFAOYSA-N |
ZM 39923 HCl is a small-molecule Janus kinase inhibitor targeting JAK3 and JAK1, with minimal activity against JAK2. By blocking JAK kinase activity, it inhibits downstream STAT protein phosphorylation and suppresses the JAK/STAT signaling pathway. This blockade impairs cytokine-mediated signal transduction, resulting in reduced cell proliferation and attenuated inflammatory immune responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(81.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.