CAS No. 193000-39-4
| IUPAC Name | 4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol;hydrochloride | |
|---|---|---|
| CAS Number | 193000-39-4 | |
| Molecular Formula |
C22H18FN3O2.HCl |
|
| Molecular Weight (MW) | 411.86 | |
| SMILES | CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl | |
| InChIKey | AVRHWGLIYGJSOD-UHFFFAOYSA-N |
ZM 323881 HCl is a potent and selective vascular endothelial growth factor receptor 2 inhibitor targeting VEGFR2 (IC50 < 2 nM). It displays marked selectivity over related receptor tyrosine kinases, including VEGFR1, PDGFRβ, FGFR1, EGFR, and ErbB2. By blocking VEGFR2 activation and downstream intracellular signaling, ZM 323881 HCl suppresses VEGF-stimulated endothelial cell proliferation and capillary-like tubule formation, thereby attenuating angiogenesis.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(24.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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