CAS No. 308277-46-5
Batch:
Purity:97
Chemical Structure
Check the
ZLc002
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | methyl (2S)-2-[(3-methoxy-3-oxopropanoyl)amino]-3-methylbutanoate | |
|---|---|---|
| CAS Number | 308277-46-5 | |
| Molecular Formula |
C10H17NO5 |
|
| Molecular Weight (MW) | 231.25 | |
| SMILES | COC(=O)CC(=O)NC(C(C)C)C(=O)OC | |
| InChIKey | BWPKYDAJBOUZDX-VIFPVBQESA-N |
Biological Activity
ZLc-002 is a selective small-molecule inhibitor of the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and carboxy-terminal PDZ ligand of nNOS (CAPON/NOS1AP). Uncoupling this complex disrupts NMDA receptor-mediated downstream signaling. This impairment of nNOS-CAPON coupling suppresses inflammatory nociception and chemotherapy-induced neuropathic pain, and systemic administration produces anxiolytic-like behavioral effects in animal models. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(198.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 46 mg/mL |
| Ethanol | 46 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.