CAS No. 2254001-81-3
Batch:
Purity:99.86
Chemical Structure
Check the
ZK824859
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[[6-[3-[3-(aminomethyl)phenyl]-5-methylphenoxy]-3,5-difluoro-2-pyridinyl]oxy]butanoic acid | |
|---|---|---|
| CAS Number | 2254001-81-3 | |
| Molecular Formula |
C22H20F2N2O4 |
|
| Molecular Weight (MW) | 414.40 | |
| SMILES | CCC(C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F | |
| InChIKey | CVNXUNVHFJANHX-HXUWFJFHSA-N |
ZK824859 is a potent and selective inhibitor of urokinase plasminogen activator (uPA), displaying target selectivity over tissue plasminogen activator (tPA) and plasmin. By blocking uPA enzymatic activity, ZK824859 impairs the plasminogen activation cascade, thereby reducing downstream extracellular matrix degradation and suppressing signaling pathways that mediate tumor cell invasion, migration, and tissue remodeling. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(207.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 86 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.