CAS No. 1628260-79-6

Batch: Purity:99.48
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Ziritaxestat (GLPG1690) Chemical Structure
Chemical Structure
Check the Ziritaxestat (GLPG1690) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile
CAS Number 1628260-79-6
Molecular Formula

C30H33FN8O2S
Molecular Weight (MW) 588.70
SMILES CCC1=C(N2C=C(C=C(C2=N1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)C5=NC(=C(S5)C#N)C6=CC=C(C=C6)F
InChIKey REQQVBGILUTQNN-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ziritaxestat (GLPG1690) is a potent and selective autotaxin inhibitor. By targeting autotaxin activity, it effectively blocks the enzymatic conversion of lysophosphatidylcholine into lysophosphatidic acid, thereby suppressing the ATX/LPA signaling axis. Downstream, this targeted inhibition reduces cell migration, fibroblast activation, extracellular matrix accumulation, and pro-fibrotic tissue remodeling in animal models of pulmonary fibrosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (169.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.