CAS No. 591239-68-8

Batch: Purity:99.89
Check CoA
ZINC05007751 Chemical Structure
Chemical Structure
Check the ZINC05007751 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5Z)-4-methyl-2,6-dioxo-5-[(5-phenylfuran-2-yl)methylidene]pyridine-3-carbonitrile
CAS Number 591239-68-8
Molecular Formula

C18H12N2O3
Molecular Weight (MW) 304.3
SMILES CC\1=C(C#N)C(=O)NC(=O)C1=C\C2=CC=C(O2)C3=CC=CC=C3
InChIKey SNLNUUWCOAPJED-ZROIWOOFSA-N

Biological Activity

ZINCis a small-molecule inhibitor of NIMA-related kinase NEK6 (IC50 =. By targeting NEK6, this agent disrupts mitotic spindle assembly and cell cycle progression, leading to antiproliferative activity across human cancer cell lines. Furthermore, ZINCexhibits synergistic antitumor effects when combined with Cisplatin and Paclitaxel in BRCA2-mutated ovarian cancer cells, demonstrating enhanced chemosensitization in drug-resistant tumor phenotypes. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 9 mg/mL (29.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] De Donato M, et al. Sci Rep. 2018;8(1):16047.

Jump to

Note: Technical data last updated: Sep 1, 2026.