CAS No. 557782-81-7

Batch: Purity:99.44
Check CoA
ZINC00881524 (ROCK inhibitor) Chemical Structure
Chemical Structure
Check the ZINC00881524 (ROCK inhibitor) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide
CAS Number 557782-81-7
Molecular Formula

C21H20N2O3S
Molecular Weight (MW) 380.46
SMILES COC1=C(C=C(C=C1)CC(=O)NC2=NC3=C(S2)CCC4=CC=CC=C43)OC
InChIKey DQNMDJGZWFZNHS-UHFFFAOYSA-N

Ordering Information

Biological Activity

ZINC00881524 acts as a selective inhibitor of Rho-associated protein kinase (ROCK), a key serine/threonine kinase regulating actin cytoskeleton dynamics. By suppressing ROCK signaling, this compound interrupts downstream phosphorylation of myosin light chain and LIM kinase, modulating focal adhesion assembly, cell contraction, and cell migration. ROCK inhibition further regulates vascular tone, endothelial barrier function, and cellular morphogenetic processes. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 76 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.