CAS No. 2173390-30-0
Batch:
Purity:99.02
Chemical Structure
Check the
Zilurgisertib fumarate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-amino-N-(4-hydroxy-1-bicyclo[2.2.2]octanyl)-5-[4-[(1R,5S)-3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]pyridine-3-carboxamide;(E)-but-2-enedioic acid | |
|---|---|---|
| CAS Number | 2173390-30-0 | |
| Molecular Formula |
C30H38N4O3.xC4H4O4 |
|
| Molecular Weight (MW) | 618.72 | |
| InChIKey | JYMHACJJTJNBGE-XESJLZEZSA-N |
Biological Activity
Zilurgisertib fumarate is an oral, potent, and selective inhibitor of activin receptor-like kinase 2 (ALK2, also known as ACVR1). By suppressing ALK2 activity, it inhibits downstream bone morphogenetic protein (BMP) signaling and SMAD pathway activation. This targeted inhibition reduces pathological osteogenic signaling to fully suppress injury-induced heterotopic ossification and downregulates hepatic hepcidin expression to regulate iron homeostasis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(161.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 30 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.