CAS No. 118569-21-4
Batch:
Purity:99.74
Chemical Structure
Check the
Zileuton sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium 1-[1-(1-benzothiophen-2-yl)ethyl]-1-oxidourea | |
|---|---|---|
| CAS Number | 118569-21-4 | |
| Molecular Formula |
C11H11N2NaO2S |
|
| Molecular Weight (MW) | 258.27 | |
| InChIKey | USURPRPAYRQEOV-UHFFFAOYSA-N |
Biological Activity
Zileuton sodium is a potent and selective inhibitor of 5-lipoxygenase (5-LOX) that exhibits strong anti-inflammatory activity. By specifically blocking 5-LOX enzymatic function, the compound suppresses downstream leukotriene biosynthesis and attenuates inflammatory signal transduction pathways. In preclinical rodent models, target inhibition effectively reduces systemic and tumor-associated inflammation, resulting in decreased polyp formation and reduced intestinal tumorigenesis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
52 mg/mL
(201.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.