CAS No. 2739829-00-4
Batch:
Purity:99.06
Chemical Structure
Check the
Zidesamtinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (19R)-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,9,10,11,23-hexazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine | |
|---|---|---|
| CAS Number | 2739829-00-4 | |
| Molecular Formula |
C22H22FN7O |
|
| Molecular Weight (MW) | 419.46 | |
| InChIKey | DTWUUAFTYSMNQX-GFCCVEGCSA-N |
Zidesamtinib (NVL-520) is a brain-penetrating macrocyclic tyrosine kinase inhibitor that potently targets wild-type ROS1 (ICof. Selective inhibition of ROS1 kinase activity by zidesamtinib suppresses downstream ERK and AKT signaling cascades in ROS1 fusion-positive cancer models. Consequently, this targeted inhibition blocks oncogenic signal transduction, reducing cancer cell viability and suppressing tumor proliferation.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.