CAS No. 3316-02-7
Batch:
Purity:99.63
Chemical Structure
Check the
ζ-Stat (NSC37044)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-hydroxynaphthalene-1,3,6-trisulfonic acid | |
|---|---|---|
| CAS Number | 3316-02-7 | |
| Molecular Formula |
C10H8O10S3 |
|
| Molecular Weight (MW) | 384.36 | |
| SMILES | OC1=CC(=CC2=CC(=CC(=C12)[S](O)(=O)=O)[S](O)(=O)=O)[S](O)(=O)=O | |
| InChIKey | KMXMLAGYNHELHA-UHFFFAOYSA-N |
ζ-Stat (NSC37044) is a specific, atypical inhibitor of protein kinase Cζ (PKCζ) with an IC50 of 5 μM. Targeted inhibition of PKCζ attenuates downstream signaling pathways, including those involved in epithelial-mesenchymal transition and cytoskeletal remodeling. Consequently, treatment with ζ-Stat decreases cell proliferation, suppresses cell migration and invasion, and induces apoptosis across various cancer cell lines in vitro.[1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 39 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.