CAS No. 413599-62-9
Batch:
Purity:99.65
Chemical Structure
Check the
ZD-4190
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine | |
|---|---|---|
| CAS Number | 413599-62-9 | |
| Molecular Formula |
C19H16BrFN6O2 |
|
| Molecular Weight (MW) | 459.27 | |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCCN4C=CN=N4 | |
| InChIKey | YBTGTVGEKMZEQX-UHFFFAOYSA-N |
ZD-4190 is an orally active VEGF receptor tyrosine kinase inhibitor that targets KDR and Flt-1. By selectively inhibiting VEGF receptor activity, ZD-4190 blocks downstream receptor autophosphorylation and VEGF-mediated signaling cascades. This inhibition suppresses VEGF-induced endothelial cell proliferation and vascular permeability, resulting in the inhibition of tumor angiogenesis and broad-spectrum tumor growth. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(26.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.