CAS No. 2272904-53-5
Batch:
Purity:99.91
Chemical Structure
Check the
Zasocitinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-1-pyridin-2-yl-3-pyridinyl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide | |
|---|---|---|
| CAS Number | 2272904-53-5 | |
| Molecular Formula |
C23H24N8O3 |
|
| Molecular Weight (MW) | 460.49 | |
| InChIKey | BWINBHTTZLVXGT-NVXWUHKLSA-N |
Zasocitinib (TAK- is a highly selective, allosteric tyrosine kinase 2 (TYK2) inhibitor. By specifically targeting the TYK2 pseudokinase (Janus homology 2, JH2) domain, it suppresses TYK2 kinase activity and inhibits downstream STAT protein phosphorylation. This disrupts signal transduction induced by IL-12, IL-23, and type I interferons, resulting in the downregulation of pro-inflammatory cytokine pathways and suppression of autoimmune disease phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
31 mg/mL
(67.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.