CAS No. 1691249-45-2
Batch:
Purity:99.79
Chemical Structure
Check the
Zanubrutinib (BGB-3111)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7S)-2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | |
|---|---|---|
| CAS Number | 1691249-45-2 | |
| Molecular Formula |
C27H29N5O3 |
|
| Molecular Weight (MW) | 471.55 | |
| SMILES | C=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N | |
| InChIKey | RNOAOAWBMHREKO-QFIPXVFZSA-N |
Zanubrutinib (BGB-3111) is a potent, selective, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with lower off-target inhibitory activity against ITK, JAK3, and EGFR. By covalently binding to the active site of BTK, it blocks B-cell receptor (BCR) signaling and downstream PLCγ2 activation, leading to inhibition of B-cell proliferation, survival, and cellular adhesion in hematologic malignancies. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Zanubrutinib (BGB-3111) Clinical Trials
- Zanubrutinib (BGB-3111) Solubility in DMSO
- Zanubrutinib (BGB-3111) Stock Solution
- Zanubrutinib (BGB-3111) Storage
- Zanubrutinib (BGB-3111) Stability
- Zanubrutinib (BGB-3111) Molecular Weight
- Zanubrutinib (BGB-3111) SMILES
- Zanubrutinib (BGB-3111) Chemical Structure (2D and 3D)
- Zanubrutinib (BGB-3111) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.