CAS No. 1931994-81-8
Batch:
Purity:99.8
Chemical Structure
Check the
Zabedosertib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[6-(2-hydroxypropan-2-yl)-2-(2-methylsulfonylethyl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 1931994-81-8 | |
| Molecular Formula |
C20H21F3N4O4S |
|
| Molecular Weight (MW) | 470.47 | |
| SMILES | CC(C)(O)C1=CC2=N[N](CC[S;v6](C)(=O)=O)C=C2C=C1NC(=O)C3=CC=CC(=N3)C(F)(F)F | |
| InChIKey | OQAMEEFUUFJZRS-UHFFFAOYSA-N |
Zabedosertib (BAY 1834845) is a potent inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). By target-specific inhibition of IRAK4 kinase activity, it interrupts Toll-like receptor and interleukin-1 receptor signaling pathways. This blockade impairs downstream activation of pro-inflammatory transcription factors, suppressing the release of inflammatory cytokines such as TNF-α, IL-1β, and IL-, thereby mediating broad anti-inflammatory and immunomodulatory effects in innate immune responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.