CAS No. 1223877-07-3
Batch:
Purity:98.867
Chemical Structure
Check the
Z218484536
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(E)-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylideneamino]urea | |
|---|---|---|
| CAS Number | 1223877-07-3 | |
| Molecular Formula |
C11H10FN5O |
|
| Molecular Weight (MW) | 247.23 | |
| InChIKey | GIZRLVBPWGRRNX-GIDUJCDVSA-N |
Z218484536 is a selective and brain-penetrant inhibitor of phosphoserine phosphatase (PSPH), a key enzyme in the L-serine biosynthesis pathway. Inhibition of PSPH blocks the enzymatic conversion of O-phospho-L-serine to L-serine, thereby suppressing de novo serine biosynthesis and disrupting downstream metabolic networks. This targeted blockade depletes essential biological precursors required for nucleotide synthesis and cellular homeostasis, ultimately impairing cancer cell survival and proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.