CAS No. 2742732-92-7
Chemical Structure
Check the
YX968
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S,4R)-1-[(2S)-3,3-dimethyl-2-[8-[4-[4-(propylaminocarbamoyl)phenyl]piperazin-1-yl]octanoylamino]butanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2742732-92-7 | |
| Molecular Formula | ||
| InChIKey | KBTKRNXLECYGBY-NERSTHRASA-N |
Biological Activity
YX968 is a synthetic proteolysis targeting chimera (PROTAC) that functions as a dual degrader of histone deacetylase 3 (HDAC3) and HDAC8. Targeted degradation of HDAC3 and HDAC8 perturbs epigenetic histone deacetylation dynamics, impairing chromatin remodeling and transcriptional regulation in cancer cells. Consequently, this selective degradation leads to cell cycle arrest, inhibition of cell proliferation, and induction of apoptotic cell death in vitro. [1]
Solubility
Reference
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Note: Technical data last updated: Sep 1, 2026.