CAS No. 1943733-16-1

Batch: Purity:99.69
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YU238259 Chemical Structure
Chemical Structure
Check the YU238259 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[(4-methoxyphenyl)sulfonylamino]methyl]benzamide
CAS Number 1943733-16-1
Molecular Formula

C22H22ClN3O4S
Molecular Weight (MW) 459.95
SMILES COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=NC=C(C=C3)Cl
InChIKey BIHURSOREGLQBB-UHFFFAOYSA-N

Ordering Information

Biological Activity

YU238259 is a selective inhibitor of homology-dependent DNA repair (HDR) that does not inhibit non-homologous end-joining (NHEJ). By specifically blocking the HDR pathway without impairing NHEJ mechanisms, YU238259 compromises double-strand break repair capacity in DNA repair-deficient cells. This pathway-specific inhibition leads to increased genomic instability, induction of synthetic lethality, and significant suppression of cellular proliferation in susceptible cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.