CAS No. 2454246-18-3
Batch:
Purity:99.98
Chemical Structure
Check the
YQ128
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide | |
|---|---|---|
| CAS Number | 2454246-18-3 | |
| Molecular Formula |
C27H29ClN2O4S2 |
|
| Molecular Weight (MW) | 545.11 | |
| SMILES | CCCOC1=C(CN(CCC2=CC=C(C=C2)[S](=O)(=O)NCC#C)C(=O)CC3=CSC=C3)C=C(Cl)C=C1 | |
| InChIKey | SFPYRFRNYALLHS-UHFFFAOYSA-N |
YQ128 is a selective inhibitor of the NLRP3 inflammasome with an IC50 of 0.30 μM. Designed as a novel chemical scaffold to target NLRP3-driven inflammation, YQ128 effectively blocks NLRP3 inflammasome activation. Experimental evaluations in both in vitro and in vivo models confirm its selective NLRP3 inhibition and significant brain penetration, supporting its therapeutic potential for neurodegenerative and central nervous system disorders. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.