CAS No. 1273323-67-3
Batch:
Purity:99.49
Chemical Structure
Check the
YLF-466D
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1273323-67-3 | |
|---|---|---|
| Molecular Formula |
C29H20CINO3 |
|
| Molecular Weight (MW) | 465.93 |
Biological Activity
YLF-466D is a small-molecule activator of AMP-activated protein kinase (AMPK). Activation of AMPK by YLF-466D stimulates endothelial nitric oxide synthase (eNOS) phosphorylation, which elevates cyclic nucleotide levels (cGMP and cAMP) and induces vasodilator-stimulated phosphoprotein (VASP) phosphorylation. Downstream, this signaling axis suppresses platelet activation, inhibiting agonist-induced platelet aggregation and attenuating collagen-stimulated whole blood aggregation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.