CAS No. 2172617-15-9
Batch:
Purity:99.82
Chemical Structure
Check the
YKL 06-061
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-cyclobutyl-3-(2,6-dimethylphenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one | |
|---|---|---|
| CAS Number | 2172617-15-9 | |
| Molecular Formula |
C30H37N7O2 |
|
| Molecular Weight (MW) | 527.66 | |
| SMILES | CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC | |
| InChIKey | GVBAXIVNAHMIGH-UHFFFAOYSA-N |
YKL 06-061 is a potent, small-molecule salt-inducible kinase (SIK) inhibitor targeting SIK1, SIK2, and SIK3. Inhibition of SIK signaling leads to dephosphorylation and nuclear translocation of CREB regulated transcription coactivators (CRTCs) and class IIa HDACs, modulating downstream gene expression. This pathway regulates macrophage polarization, suppressing pro-inflammatory cytokine production while enhancing anti-inflammatory mediator release.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(37.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.