CAS No. 1936529-65-5

Batch: Purity:99.88
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YKL-05-099 Chemical Structure
Chemical Structure
Check the YKL-05-099 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2-chloro-6-methylphenyl)-7-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-1-(5-methoxy-2-pyridinyl)-4H-pyrimido[4,5-d]pyrimidin-2-one
CAS Number 1936529-65-5
Molecular Formula

C32H34ClN7O3
Molecular Weight (MW) 600.11
SMILES CC1=C(C(=CC=C1)Cl)N2CC3=CN=C(N=C3N(C2=O)C4=NC=C(C=C4)OC)NC5=C(C=C(C=C5)C6CCN(CC6)C)OC
InChIKey VQINULODWGEVBB-UHFFFAOYSA-N

Ordering Information

Biological Activity

YKL-05-099 is a potent, small-molecule inhibitor of salt-inducible kinase (SIK) isoforms, targeting SIK1, SIK2, and SIK3. By suppressing SIK activity, it disrupts the phosphorylation of downstream substrates such as CRTC3 and HDAC4/5, driving the expression of anti-inflammatory cytokines including IL-10 while suppressing pro-inflammatory mediators. This pathway modulation promotes regulatory macrophage phenotypes and modulates immune responses in cellular models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (166.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.