CAS No. 1037184-44-3

Batch: Purity:99.93
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YK-4-279 Chemical Structure
Chemical Structure
Check the YK-4-279 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one
CAS Number 1037184-44-3
Molecular Formula

C17H13Cl2NO4
Molecular Weight (MW) 366.20
SMILES COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O
InChIKey HLXSCTYHLQHQDJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

YK-4-279 is a small-molecule inhibitor that targets the interaction between the oncogenic fusion protein EWS-FLI1 and RNA helicase A (RHA). By disrupting EWS-FLI1 binding to RHA, YK-4-279 inhibits downstream EWS-FLI1-mediated transcriptional activity, arrests cell cycle progression, induces apoptosis, and suppresses cell proliferation in Ewing sarcoma cells. Furthermore, YK-4-279 demonstrates potent antitumor activity by inhibiting tumor growth in Ewing sarcoma xenograft animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 73 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.