CAS No. 1215281-19-8
Batch:
Purity:99.99
Chemical Structure
Check the
YK 3-237
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1215281-19-8 | |
|---|---|---|
| Molecular Formula |
C19H21BO7 |
|
| Molecular Weight (MW) | 372.18 | |
| SMILES | COC1=C(OC)C(=CC(=C1)C(=O)/C=C/C2=CC=C(OC)C(=C2)B(O)O)OC |
YK-3-237 is a small-molecule activator of sirtuin 1 (SIRT1). By activating SIRT1-mediated deacetylation, YK-3-237 promotes the depletion of mutant p53 protein levels and upregulates downstream pro-apoptotic target genes such as PUMA and NOXA. Consequently, this pathway modulation triggers PARP-dependent apoptosis, induces cell cycle arrest at the G2/M phase, and suppresses the proliferation of triple-negative breast cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(198.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.