CAS No. 3053716-98-3
Batch:
Purity:97.20
Chemical Structure
Check the
YJ1206
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-benzyl-1-[6-[4-[1-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperidin-4-yl]piperazin-1-yl]-3-pyridinyl]-1-[4-(quinazolin-2-ylamino)cyclohexyl]urea | |
|---|---|---|
| CAS Number | 3053716-98-3 | |
| Molecular Formula |
C49H52FN11O5 |
|
| Molecular Weight (MW) | 894.01 | |
| InChIKey | SEWFPOHTHJEBQK-UHFFFAOYSA-N |
Biological Activity
YJ1206 is an orally bioavailable, highly specific, and potent degrader targeting cyclin-dependent kinases 12 and 13 (CDK12/13). By promoting the degradation of CDK12 and CDK13, it disrupts transcriptional regulation, increases intracellular DNA damage, and induces apoptosis in cancer cells. Downstream disruption of these catalytic complexes severely impairs genomic stability pathways, leading to robust anti-tumor activity in vivo.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(111.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.