CAS No. 1311423-89-8
| IUPAC Name | N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide | |
|---|---|---|
| CAS Number | 1311423-89-8 | |
| Molecular Formula |
C20H22ClF3N2O3 |
|
| Molecular Weight (MW) | 430.85 | |
| SMILES | CCOC1=C(C(=CC=C1)OCCN(C)C)C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F | |
| InChIKey | TZHLDFAKTWDTOW-UHFFFAOYSA-N |
YF-2 is a blood-brain barrier permeable activator of histone acetyltransferases, demonstrating selectivity for CBP alongside activation of PCAF, GCN5, and p300. By enhancing histone acetyltransferase enzymatic activity, YF-2 promotes histone hyperacetylation and downstream transcription, facilitating chromatin remodeling associated with synaptic plasticity and neuroprotective signaling pathways. These molecular effects enhance central nervous system function and cognitive performance in preclinical studies. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 86 mg/mL |
| Ethanol | 86 mg/mL |
| Ethanol | 86 mg/mL |
| DMSO |
22 mg/mL
(51.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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