CAS No. 1311423-89-8
Batch:
Purity:99.98
Chemical Structure
Check the
YF-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide | |
|---|---|---|
| CAS Number | 1311423-89-8 | |
| Molecular Formula |
C20H22ClF3N2O3 |
|
| Molecular Weight (MW) | 430.85 | |
| SMILES | CCOC1=C(C(=CC=C1)OCCN(C)C)C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F | |
| InChIKey | TZHLDFAKTWDTOW-UHFFFAOYSA-N |
Biological Activity
YF-2 is a blood-brain barrier permeable activator of histone acetyltransferases, demonstrating selectivity for CBP alongside activation of PCAF, GCN5, and p300. By enhancing histone acetyltransferase enzymatic activity, YF-2 promotes histone hyperacetylation and downstream transcription, facilitating chromatin remodeling associated with synaptic plasticity and neuroprotective signaling pathways. These molecular effects enhance central nervous system function and cognitive performance in preclinical studies. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 86 mg/mL |
| Ethanol | 86 mg/mL |
| Ethanol | 86 mg/mL |
| DMSO |
22 mg/mL
(51.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.