CAS No. 2951015-29-3
Batch:
Purity:99.01
Chemical Structure
Check the
YD23
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-[2-[4-[[4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]-2-fluorophenoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | |
|---|---|---|
| CAS Number | 2951015-29-3 | |
| Molecular Formula |
C38H39FN8O7 |
|
| Molecular Weight (MW) | 738.77 | |
| InChIKey | DMUYROJVOXZRNE-UHFFFAOYSA-N |
YD23 is a proteolysis targeting chimera (PROTAC) that selectively induces the degradation of SMARCA2. By targeting the SWI/SNF chromatin remodeling complex subunit, SMARCA2 degradation reduces chromatin accessibility at gene enhancers governing cell cycle regulation and cell growth pathways. Consequently, this downregulation of cell cycle genes selectively inhibits the proliferation and growth of SMARCA4-mutant non-small cell lung cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(135.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.