CAS No. 1832671-96-1
Batch:
Purity:99.92
Chemical Structure
Check the
Y06036
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-bromo-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 1832671-96-1 | |
| Molecular Formula |
C16H15BrN2O5S |
|
| Molecular Weight (MW) | 427.27 | |
| SMILES | CC1=NOC2=CC(=C(C=C12)NS(=O)(=O)C3=C(C=CC(=C3)Br)OC)OC | |
| InChIKey | KVGNGFGTOSOVPB-UHFFFAOYSA-N |
Y06036 is a potent and selective inhibitor of the bromodomain and extra-terminal (BET) family, targeting the BRD4(1) bromodomain. By blocking the binding of BET proteins to acetylated lysine residues on histones, Y06036 disrupts chromatin remodeling and downregulates downstream oncogenic gene expression programs, such as MYC signaling. This inhibition suppresses tumor cell proliferation and demonstrates robust antitumor activity across various preclinical cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.