CAS No. 1234480-50-2

Batch: Purity:99.98
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XMD8-92 Chemical Structure
Chemical Structure
Check the XMD8-92 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-ethoxy-4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number 1234480-50-2
Molecular Formula

C26H30N6O3
Molecular Weight (MW) 474.55
SMILES CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C
InChIKey QAPAJIZPZGWAND-UHFFFAOYSA-N

Biological Activity

XMD8-92 is a potent dual inhibitor of big MAP kinase 1 (BMK1/ERK5) and bromodomain-containing proteins, including BRD4. By targeting BMK1/ERK5, XMD8-92 blocks BMK1 autophosphorylation and prevents the downstream phosphorylation and degradation of promyelocytic leukemia (PML) protein. This pathway inhibition leads to PML stabilization, cell cycle arrest, and suppression of tumor growth across preclinical cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (168.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Yang Q, et al. Cancer Cell. 2010;18(3):258-67.

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Note: Technical data last updated: Sep 1, 2026.