CAS No. 1234479-76-5
Batch:
Purity:99.97
Chemical Structure
Check the
XMD8-85 (ERK5-IN-1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one | |
|---|---|---|
| CAS Number | 1234479-76-5 | |
| Molecular Formula |
C25H29N7O2 |
|
| Molecular Weight (MW) | 459.54 | |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C)OC | |
| InChIKey | DDTPGANIPBKTNU-UHFFFAOYSA-N |
XMD8-85 is a selective and potent dual kinase inhibitor of ERK5 and LRRK2. By suppressing ERK5 and LRRK2 kinase activities, XMD8-85 blocks downstream MAPK cascade activation and cellular signaling pathways. This inhibition impairs transcription factor activation, resulting in suppressed cell proliferation and altered cellular phenotypes in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.