CAS No. 1628614-50-5
Batch:
Purity:99.15
Chemical Structure
Check the
XMD-17-51
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,11-dimethyl-2-[(1-piperidin-4-ylpyrazol-4-yl)amino]pyrimido[4,5-b][1,4]benzodiazepin-6-one | |
|---|---|---|
| CAS Number | 1628614-50-5 | |
| Molecular Formula |
C21H24N8O
|
|
| Molecular Weight (MW) | 404.47 | |
| SMILES | CN1C2=CC=CC=C2C(=O)N(C3=CN=C(N=C31)NC4=CN(N=C4)C5CCNCC5)C | |
| InChIKey | LKOFXMLMYKWELM-UHFFFAOYSA-N |
XMD-17-51 is a potent and highly selective kinase inhibitor targeting NUAK1 (also known as ARK5). Inhibition of NUAK1 attenuates LKB1-dependent signaling pathways, leading to reduced phosphorylation of downstream substrates such as MYPT1. Disruption of NUAK1 activity impairs cell motility, proliferation, and survival in MYC-driven cancer cells, highlighting its critical role in cellular metabolic adaptation and tumor progression. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.