CAS No. 1251156-08-7
Batch:
Purity:99.66
Chemical Structure
Check the
XL388
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [7-(6-amino-3-pyridinyl)-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]-(3-fluoro-2-methyl-4-methylsulfonylphenyl)methanone | |
|---|---|---|
| CAS Number | 1251156-08-7 | |
| Molecular Formula |
C23H22FN3O4S |
|
| Molecular Weight (MW) | 455.5 | |
| SMILES | CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N | |
| InChIKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
Biological Activity
XL388 is a selective, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR). Inhibition of mTOR disrupts signaling through the AKT/mTOR pathway by targeting both mTORC1 and mTORC2 complexes. Downstream, this suppression impairs cellular growth, nutrient sensing, and metabolic homeostasis, ultimately leading to reduced cell proliferation and survival in targeted cellular models. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
1.25 mg/mL
(2.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.