CAS No. 2417089-74-6

Batch: Purity:98.77
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XL177A Chemical Structure
Chemical Structure
Check the XL177A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(4S)-4-benzyl-5-[4-hydroxy-4-[[7-[3-(4-methylpiperazin-1-yl)propanoylamino]-4-oxoquinazolin-3-yl]methyl]piperidin-1-yl]-5-oxopentyl]-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide
CAS Number 2417089-74-6
Molecular Formula

C47H57ClN8O5
Molecular Weight (MW) 849.46
SMILES CN1CCN(CC1)CCC(=O)NC2=CC3=C(C=C2)C(=O)N(CC4(O)CCN(CC4)C(=O)C(CCCNC(=O)C5=CC6=C(C=C5)[Cl]=C7CCCCC7=N6)CC8=CC=CC=C8)C=N3
InChIKey UYJWYMWIVMCGQZ-DHUJRADRSA-N

Biological Activity

XL177A is a potent, selective, and irreversible inhibitor of ubiquitin-specific peptidase 7 (USP7). By target-specific inhibition of USP7 deubiquitinating activity, XL177A disrupts protein homeostasis and regulates the p53 pathway. Inhibition of USP7 prevents the deubiquitination and stabilization of substrate proteins, leading to suppressed tumor cell proliferation and enhanced apoptosis. This agent serves as a valuable tool for dissecting USP7-dependent signaling mechanisms in cancer biology. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (117.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Turnbull AP, et al. Nature. 2017;550(7677):481-486.

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Note: Technical data last updated: Sep 1, 2026.