CAS No. 2367004-54-2

Batch: Purity:99.78
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XL092 Chemical Structure
Chemical Structure
Check the XL092 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-N'-(4-fluorophenyl)-1-N-[4-[7-methoxy-6-(methylcarbamoyl)quinolin-4-yl]oxyphenyl]cyclopropane-1,1-dicarboxamide
CAS Number 2367004-54-2
Molecular Formula

C29H25FN4O5
Molecular Weight (MW) 528.53
SMILES CNC(=O)C1=CC2=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3)C=CN=C2C=C1OC
InChIKey JSPCKALGNNVYOO-UHFFFAOYSA-N

Ordering Information

Biological Activity

XL092 is an ATP-competitive multi-targeted receptor tyrosine kinase inhibitor targeting MET, VEGFR2, AXL, and MER. Inhibition of these signaling pathways suppresses receptor phosphorylation and blocks angiogenic and oncogenic survival mechanisms. Downstream cellular responses include repolarization of tumor-associated macrophages from M2 to M1 phenotypes, inhibition of efferocytosis, and decreased tumor microvasculature, ultimately driving potent tumor growth inhibition and enhanced immune cell infiltration. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (189.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.