CAS No. 14293-44-8
Batch:
Purity:99.79
Chemical Structure
Check the
Xipamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 14293-44-8 | |
|---|---|---|
| Molecular Formula |
C15H15ClN2O4S |
|
| Molecular Weight (MW) | 354.81 | |
| SMILES | CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N |
Biological Activity
Xipamide is a sulfonamide-derived diuretic and saluretic agent that targets solute transport in the renal tubule. It acts primarily by inhibiting sodium and chloride reabsorption in the cortical segment of the ascending limb and the distal convoluted tubule. This selective inhibition disrupts renal electrolyte transport pathways, promoting the excretion of sodium, chloride, and water to exert potent saluretic and diuretic effects.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(197.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.