CAS No. 122955-13-9
Batch:
Purity:99.24
Chemical Structure
Check the
XE991 dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride | |
|---|---|---|
| CAS Number | 122955-13-9 | |
| Molecular Formula |
C26H22Cl2N2O |
|
| Molecular Weight (MW) | 449.37 | |
| SMILES | Cl.Cl.O=C1C2=CC=CC=C2C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15 | |
| InChIKey | WOGWMARIFDNZON-UHFFFAOYSA-N |
XE991 dihydrochloride is a potent Kv7 (KCNQ) channel blocker that selectively inhibits Kv7.1, Kv7.2, heteromeric Kv7.2/Kv7.3, and native M-current. Blockade of these voltage-gated potassium channels suppresses hyperpolarizing neuronal M-currents, leading to cell membrane depolarization, increased neuronal excitability, and enhanced neurotransmitter release across neuronal pathways. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 90 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.