CAS No. 725247-18-7
Batch:
Purity:99.66
Chemical Structure
Check the
XCT790
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide | |
|---|---|---|
| CAS Number | 725247-18-7 | |
| Molecular Formula |
C23H13F9N4O3S |
|
| Molecular Weight (MW) | 596.42 | |
| SMILES | COC1=C(C=CC(=C1)C=C(C#N)C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F | |
| InChIKey | HQFNFOOGGLSBBT-AWNIVKPZSA-N |
XCT790 is a potent and selective inverse agonist of estrogen-related receptor α (ERRα) with an IC50 of, displaying no activity against ERRγ, ERα, or ERβ. By inhibiting ERRα-mediated transcriptional activity, XCT790 disrupts mitochondrial function and oxidative energy metabolism, which suppresses cellular proliferation, tumor growth, and angiogenesis while inducing apoptotic cell death in cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(13.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.