CAS No. 2863686-82-0
Batch:
Purity:98.86
Chemical Structure
Check the
X1 compound
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(1H-benzimidazol-2-yl)-5-(3-phenylmethoxyphenyl)-1H-indazole | |
|---|---|---|
| CAS Number | 2863686-82-0 | |
| Molecular Formula |
C27H20N4O |
|
| Molecular Weight (MW) | 416.48 | |
| SMILES | C(OC1=CC(=CC=C1)C2=CC=C3[NH]N=C(C4=NC5=C([NH]4)C=CC=C5)C3=C2)C6=CC=CC=C6 | |
| InChIKey | NKMNBWKGYNRJDP-UHFFFAOYSA-N |
X1 compound is a small-molecule inhibitor targeting the RepA motif of the long non-coding RNA Xist. Binding of X1 reduces the conformational space of RepA and displaces key interacting protein factors, including PRC2 and SPEN. Consequently, this disruption suppresses histone H3K27 trimethylation, blocks the initiation of X-chromosome inactivation, and impairs female-specific cell differentiation and growth. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.