CAS No. 878557-55-2
Batch:
Purity:99.53
Chemical Structure
Check the
WRW4
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanamide | |
|---|---|---|
| CAS Number | 878557-55-2 | |
| Molecular Formula |
C61H65N15O6 |
|
| Molecular Weight (MW) | 1104.27 | |
| InChIKey | IRJDOVLLPORVJP-WOAIKHIASA-N |
WRW4 is a selective formyl peptide receptor-like 1 (FPRL1/FPR2) antagonist that inhibits WKYMVm binding to FPRL1 with an IC50 of. By blocking FPR2 activation, WRW4 inhibits agonist-induced intracellular calcium mobilization, ERK phosphorylation, and superoxide generation in human neutrophils. This targeted inhibition suppresses chemotaxis and inflammatory signaling pathways downstream of FPR2, making WRW4 a key tool for probing FPR2-mediated immune responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(90.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.