CAS No. 1243243-89-1
Batch:
Purity:99.99
Chemical Structure
Check the
Wnt-C59 (C59)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-(2-methyl-4-pyridinyl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide | |
|---|---|---|
| CAS Number | 1243243-89-1 | |
| Molecular Formula |
C25H21N3O |
|
| Molecular Weight (MW) | 379.45 | |
| SMILES | CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4 | |
| InChIKey | KHZOJCQBHJUJFY-UHFFFAOYSA-N |
Wnt-C59 is a potent inhibitor of Porcupine (PORCN) that suppresses Wnt3A-mediated TCF reporter activity with an IC50 ofin HEK293 cells. By inhibiting PORCN-catalyzed Wnt acylation, Wnt-C59 blocks Wnt protein secretion and prevents downstream Wnt/β-catenin pathway activation. Consequently, it impairs Wnt-dependent cell proliferation and suppresses tumor growth in Wnt-driven cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Wnt-C59 (C59) Mechanism of Action: PORCN Inhibition in Cancer Stem Cell Research
- Wnt-C59 (C59) Clinical Trials
- Wnt-C59 (C59) Working Concentration | Cell Culture | Treatment
- Wnt-C59 (C59) Solubility in DMSO
- Wnt-C59 (C59) Stock Solution
- Wnt-C59 (C59) Storage
- Wnt-C59 (C59) Stability
- Wnt-C59 (C59) Combination Database
- Wnt-C59 (C59) Molecular Weight
- Wnt-C59 (C59) SMILES
- Wnt-C59 (C59) Chemical Structure (2D and 3D)
- Wnt-C59 (C59) IC50 for Cell-based and Cell-free Assays
- Wnt-C59 (C59) Sigma (5.00496)? Try a better option.
- Wnt-C59 (C59) MedChemExpress (HY-15659)? Try a better option.
- Wnt-C59 (C59) Tocris (5148)? Try a better option.
- Wnt-C59 (C59) Cayman (16644)? Try a better option.
- Wnt-C59 (C59) Abcam (ab142216)? Try a better option.
- Wnt-C59 (C59) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.