CAS No. 2123489-30-3

Batch: Purity:99.87
Check CoA
WNK-IN-11 Chemical Structure
Chemical Structure
Check the WNK-IN-11 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [5-chloro-2-[2-(methylamino)-1,3-thiazol-4-yl]-4-pyridinyl]-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]methanone
CAS Number 2123489-30-3
Molecular Formula
C21H21Cl2N5OS
Molecular Weight (MW) 462.40
SMILES CNC1=NC(=CS1)C2=NC=C(C(=C2)C(=O)N3CCN(CC3)CC4=CC=C(C=C4)Cl)Cl
InChIKey MVXAYIXYYOVALX-UHFFFAOYSA-N

Ordering Information

Biological Activity

WNK-IN-11 is a potent and selective allosteric inhibitor of With-No-Lysine kinase 1 (WNK1). By targeting WNK1, it suppresses downstream STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase 1 (OSR1) signaling pathways. This inhibition impairs cation-chloride cotransporter phosphorylation, thereby regulating intracellular ion homeostasis and transepithelial transport. Consequently, WNK-IN-11 serves as a valuable chemical tool for investigating WNK-mediated kinase cascades and osmotic stress responses.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 32 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.