CAS No. 2055397-18-5
Batch:
Purity:99.86
Chemical Structure
Check the
WM-8014
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-phenylbenzohydrazide | |
|---|---|---|
| CAS Number | 2055397-18-5 | |
| Molecular Formula |
C20H17FN2O3S |
|
| Molecular Weight (MW) | 384.42 | |
| SMILES | CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3 | |
| InChIKey | PHHZKBMVRPULAW-UHFFFAOYSA-N |
WM-8014 is a potent inhibitor of histone acetyltransferase KAT6A (IC50 of 8 nM) and KAT6B (IC50 of. By blunting KAT6A/B-mediated histone acetylation, WM-8014 induces cell cycle arrest and triggers cellular senescence without causing DNA damage. This targeted inhibition effectively halts cancer cell proliferation and suppresses tumor growth in preclinical models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.