CAS No. 211555-05-4
Batch:
Purity:99.83
Chemical Structure
Check the
WHI-P97
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | |
|---|---|---|
| CAS Number | 211555-05-4 | |
| Molecular Formula |
C16H13Br2N3O3 |
|
| Molecular Weight (MW) | 455.10 | |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC | |
| InChIKey | YVCXQRVVNQMZEI-UHFFFAOYSA-N |
WHI-P97 is a quinazoline derivative that functions as a potent inhibitor of Janus kinase 3 (JAK3) and epidermal growth factor receptor (EGFR) kinase. By targeted inhibition of JAK3 and EGFR signaling complexes, WHI-P97 suppresses downstream STAT phosphorylation and receptor tyrosine kinase-mediated pathways, ultimately leading to the inhibition of cellular proliferation and the induction of apoptosis in susceptible target cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(17.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.